Australia on Monday approved the Pfizer-BioNTech COVID-19 vaccine for use but warned AstraZeneca’s international production problems mean the country would need to distribute a locally manufactured shot earlier than planned.

The country’s medical regulator was one of the first in the world to complete a comprehensive approval of the Pfizer-BioNTech vaccine, Prime Minister Scott Morrison said on Monday, noting it was a year since the first local coronavirus case was detected.

Vaccination of priority groups with the Pfizer vaccine is expected to begin in late February at 80,000 doses per week, Health Minister Greg Hunt told reporters.

Pfizer had told the Australian government it anticipated continuous supply but would provide global production guidance “in mid-February for March and beyond on a weekly basis,” he said.

The Australian rollout update comes after AstraZeneca Plc. told European Union officials on Friday it would cut deliveries of its vaccine to the bloc by 60% in the first quarter due to production problems.

Hunt said AstraZeneca had advised Australia the company has “had a significant supply shock and so that means we won’t have as much of that AstraZeneca international in March as they had previously promised”.

The AstraZeneca vaccine is yet to be approved by Australia, which expects to start CSL’s domestic supply of the AstraZeneca vaccine in March, earlier than planned, at 1 million doses a week, he said.

“The decision to pay a premium for an onshore, secure, sovereign vaccine manufacturing capacity via CSL, that puts Australia in a vastly more secure position than almost any other country in the world,” Hunt said.

Australia has set a target of 4 million vaccine doses by April. It has also committed to supplying vaccines to Pacific Island nations on a later timetable.

The Pfizer vaccine has been provisionally approved by the Therapeutic Goods Administration’s (TGA) for Australians aged 16 years and over.

Australia will administer the two doses of the vaccine to each recipient at the recommended time.